12月5日 Irfan J. Lodhi: Control of Adipose Tissue Thermogenesis


报告题目:Control of Adipose Tissue Thermogenesis
报告人:Irfan J. Lodhi,Washington University School of Medicine
主持人:杜震宇 教授
报告时间:2018年12月5日 10:00-11:30(周三)
报告地点:生命科学学院534报告厅
 
报告人简介:Irfan J. Lodhi,博士,现任华盛顿大学医学院助理教授。2007年于密歇根大学细胞与分子生物学博士毕业,2007至2011年在华盛顿大学医学院进行博士后研究工作,之后留校任教,至今从事内分泌、代谢和脂类方向的研究。在cell, cell metabolism等杂志上发表文章近30篇,现任Scientific Reports杂志的编委成员,Journal of Endocrinology, Autophagy, PLoS One, PLoS Genetics, Nature Chemical Biology, Diabetes, and Antioxidants & Redox Signaling等多个杂志的审稿人。
 
报告内容简介:Adipose tissue regulates whole body energy balance. Two major types of adipose tissue are found in mammals, white fat and brown fat. White adipose tissue (WAT) primarily stores fat. Brown adipose tissue (BAT) transforms the chemical energy in food into heat through uncoupled respiration. In addition to classical brown adipocytes, clusters of brown adipocyte-like beige cells appear in subcutaneous WAT in response to prolonged cold exposure. Brown and beige adipocytes are enriched in mitochondria and express uncoupling protein-1 (UCP1), a mitochondrial membrane protein that mediates thermogenesis by allowing protons to leak across the inner mitochondrial membrane, bypassing ATP synthase. By promoting thermogenesis, this uncoupling of oxidation from ATP production increases energy expenditure. Like mitochondria, peroxisomes are abundantly present in BAT. Peroxisomes perform essential functions in lipid metabolism, including fatty acid oxidation and plasmalogen synthesis. He will discuss their recent studies suggesting a role for peroxisomes in thermogenesis through their control of mitochondrial dynamics and function in brown and beige adipocytes.