12月18日 Ning Wang: Seeds or Soil? Tumour dormancy and interaction with bone microenvironment during the development of prostate cancer bone metastasis


报告题目:Seeds or Soil? Tumour dormancy and interaction with bone microenvironment during the development of prostate cancer bone metastasis
报告人:Dr. Ning Wang, Principle Investigator of the Mechanobiology and Cancer Biology group, University of Sheffield.
主持人:罗剑 教授
报告时间:2018年12月18日 13:00(周二下午)
报告地点:生命科学学院469会议室

报告人简介:Dr Ning Wang is a cancer biologist interested in cancer induced bone diseases and cancer cell dormancy. Dr Wang undertook his undergraduate (BSc) and postgraduate (MRes) training in biology at Ocean University of China. After moved to the UK in 2004, he studied the trend of Biotech-industry development at Loughborough University and gained his MSc in Management the following year. He then joined Professor Alison Gartland’s group in Sheffield and was awarded his PhD in 2010 for his contribution in investigating the roles of purinergic signalling in osteoporosis. Dr Wang was subsequently appointed as a Post-doctoral Research Associate in Dr Colby Eaton’s lab and took a leading role in developing the models used in the identification of dormant metastasis initiating tumour cells in a Cancer Research UK programme grant. He was then employed as a Senior Post-doctoral Research Associate in Professor Tim Skerry’s group in 2014 and worked on the Wellcome Trust sponsored programme in development of novel agents for the treatment of pancreatic cancer. He is now the Group Leader and Principle Investigator of the Mechanobiology and Cancer Biology group, University of Sheffield. His current main research interests focus on defining impact of exercise on the initiation and progression of prostate/breast cancer skeletal metastasis using pre-clinical models, which are supported by the Prostate Cancer UK Research Innovation Award (~£200,000) and Weston Park Cancer Charity Large Grant (~£90,000). His research also receives sponsor from The Royal Society and Mexican CONACyT scholarship. Over the past five years, he has authored more than 20 publications (14 articles as first and/or correspondent author, citation>400, h-index: 12) in high impact peer reviewed journals such as J Bone Miner Res, FASEB J, Stem Cell, Clin Cancer Res etc. He has demonstrated his increasing national and international profile by regularly refereeing papers for peer-reviewed international journals (e.g. JBMR, Int J Cancer, PLoS One, and Sci Rep etc) and reviewing grant applications for international funding bodies such as KWF Kankerbestrijding – Dutch Cancer Society (DCS). Dr Wang has supervised research projects for both PhD and MSc students as their primary supervisor. He has also gained the recognition as the Fellow of the Higher Education Academy (FHEA) for his contribution at teaching and training both undergraduates and postgraduates. 

报告摘要: Prostate cancer (PCa) most commonly metastasizes to the bone, causing considerable morbidity and mortality. Bone metastases could occur several years after the removal of primary tumours, indicating a longer tumour dormancy during PCa metastasis. Our previous research has shown that bone metastases are initiated by a minor subset of prostate cancer cells (<1% of total cell population) that are mitotically dormant (the ‘Seeds’) and their activation and growth are regulated by the bone microenvironment (the ‘Soil’). Our current research is focusing on further characterizing these dormant, metastasis initiating subpopulations and understanding how the changes in bone microenvironment (e.g. mechanical stimuli) affect the dormancy of these cells.