报告人简介：叶冰，博士，美国密西根大学，副教授（终身），博顿贝克生命科学讲座教授。研究兴趣：1. 神经元树突、轴突发育分化过程的分子机制，及其缺陷与人类疾病的关系；2. 神经环路形成的机制；3. 树突分泌通路在神经元发育及功能中的作用；4. 治疗神经生物学功能紊乱的有效化学分子。发表高水平论文30余篇，出版专著3部。获得多项学术荣誉，长期担任中国、美国、英国等各项基金评委，多种国际期刊的审稿人。

报告摘要：Down syndrome (DS) is a common form of intellectual disability, but the molecular mechanisms that underlie neurodevelopmental disorders in DS are poorly understood. DS is caused by the trisomy of human chromosome 21 (hCh21); different aspects of DS are caused by different genes on this chromosome. In consequence, a major hurdle in developing treatments for DS is the identification of genes and molecular pathways that are the drivers of pathogenesis and can be targeted for effective therapies. In this talk, I will present our recent work on identifying the genes that drive the pathogenesis in DS brain disorders.