5月30日 杜嘉木:Molecular basis for the epigenetic regulation of plant flowering


报告题目:Molecular basis for the epigenetic regulation of plant flowering
报告人:杜嘉木, 南方科技大学
主持人:翁杰敏 教授
报告时间:2019530日上午1030(周四上午)
报告地点:生命科学学院534小会议室


报告人简介:

杜博士于2008年中国科学院上海生命科学研究院上海生物化学与细胞生物学研究所取得博士学位。2008年到2019年间先后在中国科学院上海生物化学与细胞生物学研究所从事助理研究员、在纪念斯隆凯特琳癌症中心从事博士后、在中国科学院上海植物逆境生物学研究中心从事研究员,在中国科学院分子植物卓越创新研究中心为青年研究骨干。20192月杜博士正式加盟南方科技大学生物系。
杜博士曾获得2015年,中共中央组织部“青年千人计划”;2016年,科技部国家重点研发计划项目首席科学家(青年);2017年,国家自然科学基金委“优秀青年科学基金”;2018年,中国科学院优秀导师奖。在国际权威杂志发表论文44余篇,其中多篇文章发表在NatureSciencePNAS等顶尖杂志。同时杜博士也为PNASNature Communications15个知名杂志的审稿人,Biochemical Society Transactions的副编辑。


报告内容:

In plants, floral phase transition is a key process that conduct the conversion from vegetative growth to reproductive growth. Various environmental and internal signals can be finally transferred to the gene regulation signal to key flowering integrators, such as FT and SOC1. Thus, the flowering time is controlled by environmental signals such as day-length and temperature both genetically and epigenetically. We focus on the biochemical and structural characterization of important epigenetic regulators that influence the flowering-time. Here, we present our recent works on the histone mark readers and erasers that module plant flowering in different manners. We identified several dual-histone mark binding systems, either in one protein or in multiple proteins, can regulate flowering by the balance between different histone marks. Our structural biochemical and structural studies further revealed the molecular mechanism for the specific recognition and the dynamics between different histone marks. Our studies revealed that the importance of epigenetic mark, especially the H3K27me3 mark, plays essential role in the proper regulation of plant flowering.