报告题目：Real-Time Interrogating Stroke
报告人：贾杰敏 西湖大学
主持人：潘逸萱 博士
报告时间：2019年6月14日 10:00（周五上午）
报告地点：中北校区脑功能基因组学研究所一楼

报告人简介：
Dr. Jie-Min Jia is an assistant professor in Westlake University at Hangzhou. She received her Bachelor's Degree from Zhejiang Normal University in 2002 and Ph.D. degree in Neurobiology at Institute of Neuroscience in Chinese Academy of Sciences in 2008. Following a five-year postdoctoral research period at National Institutes of Health, she joined UTSW as an assistant instructor in 2014. In 2017, she joined Westlake University as an independent principle investigator. Dr. Jia received Di-Ao Award in 2009 and 1000 Young Talents award in 2018.

报告内容：
The precise manipulation of microcirculation in mice can facilitate mechanistic studies of brain injury and repair after ischemia, but this manipulation remains a technical challenge, particularly in conscious mice. We developed a technology that uses micromagnets to induce aggregation of magnetic nanoparticles to reversibly occlude blood flow in microvessels. This allowed induction of ischemia in a specific cortical region of conscious mice of any postnatal age, including perinatal and neonatal stages, with precise spatiotemporal control but without surgical intervention of the skull or artery. When combined with longitudinal live-imaging approaches, this technology facilitated the discovery of a feature of the ischemic cascade: selective loss of smooth muscle cells in juveniles but not adults shortly after onset of ischemia and during blood reperfusion.