报告题目：Innate lymphoid cell regulation of intestinal health and disease

报 告 人：周   磊 研究员

主 持 人：赖玉平 教授

报告时间： 2023年12月20日 15:30-16:30

报告地点：生科院534会议室

报告人简介：

周磊，本科毕业于西北农林科技大学，博士毕业于华东师范大学生命医学研究所，上海市调控生物学重点实验室。2016年，周博士前往美国康奈尔大学医学院Greg Sonnenberg实验室开展博士后研究，方向为黏膜免疫学，期间获得克罗恩和结肠炎基金会研究奖学金。2022年，周博士加入上海交大医学院附属仁济医院、上海市免疫治疗创新研究院任研究员，并入选国家和上海市海外高层次青年人才计划。周博士实验室主要利用小鼠模型并结合临床样本探究肠道菌群、免疫系统和肠神经系统在哺乳动物组织健康和疾病中的作用，研究成果以第一作者或通讯作者发表在Nature、Nature Immunology等杂志，并应邀在Immunity、Science Immunology和Nature Metabolism杂志撰写综述或评述文章。

报告内容简介：

The mammalian intestine is colonized with trillions of microorganisms, termed the microbiota, consequently, the hosts evolved a sophisticated mucosal immune system that maintains a symbiotic relationship with the microbiota. Despite this knowledge, the underlying mechanisms by which the dynamic and reciprocal dialogues between the microbiota and immune system regulate intestinal health and disease remain elusive. Dr. Zhou’s work defined a pathway of immune regulation in the healthy small intestine, in which macrophages integrate microbial derived signals, produce IL-1β, and promote group 3 innate lymphoid cell (ILC3s)-derived IL-2 to support regulatory T cells in the intestine, which is essential to maintain immunological homeostasis and oral tolerance to dietary antigens, as well as limit intestinal inflammation in mouse and human. In addition, Dr. Zhou provoked a novel paradigm of tissue-protection in the gastrointestinal tract in which ILC3s critically protect the intestinal epithelium from TNF-induced cell death through production of tissue-protective growth factor HB-EGF. These studies will advance our understanding of the pathogenesis of chronic human diseases and potentially provide opportunities for future novel preventative or therapeutic strategies targeting host-microbiota interactions.