报告题目：Pivotal roles of Interleukin-17 signaling in autoimmune encephalomyelitis
报告人：康自珍 教授
主持人：陈华青 副教授
报告时间：11月13日, 13:30-14:30（周三）
报告人简介：康自珍教授，2000年获得北京大学免疫学专业博士学位，之后在华东理工大学任副教授，曾任美国克利夫兰诊所Lerner研究所免疫学系研究员，现为交通大学医学院上海免疫学研究所任研究员。
报告摘要：Th17 cells play important roles in autoimmune diseases, infectious disease and tumor et al. IL-17 is a signature cytokine secreted by Th17 cells. While high level of IL-17 has frequently been observed in patients of multiple sclerosis(MS) and its experimental models, the actual target of IL-17 in these context is still elusive. By using conditional knockout mice of Act1, an adaptor protein of IL-17 signaling, we found that Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells, thus provide a specific target for MS therapy.
