报告题目： Meiosis: no end in sight

报 告 人： Ming-Han Tong 童明汉 研究员

邀 请 人： 翁杰敏 教授

报告时间：2025年12月9日 下午14:00-15:00

报告地点：闵行校区生科院159会议室

报告人简介：

本科、研究生就读于上海第二医科大学； 博士毕业后游学美国十余年。2013年9月15日回国，入职于中国科学院上海生物化学与细胞生物学研究所。

研究工作尝试回答“哺乳动物减数分裂如何启动”这一生命科学领域最为基础的关键科学问题, 目前已取得重要阶段性进展。

Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences

报告简介：

Mammalian spermatogenesis is a complex and asynchronous program in which diploid spermatogonia give rise to haploid spermatozoa. Using an established strategy to isolate all major spermatogenic cell types, we have generated an integrated multi-omics atlas encompassing transcriptomics, translatomics, proteomics, epigenomics, and metabolomics across male germ cell development. Two developmental junctures emerged as major systems-level transitions: (i) entry of meiosis and (ii) completion of meiotic recombination. Each transition was characterized by dramatic transcriptomic shifts, extensive epigenomic reprogramming, and pronounced metabolic remodeling. Cross-layer integration nominated a set of putative “switch” molecules with the potential to trigger meiotic initiation. However, subsequent functional testing falsified these predictions, indicating that no definitive molecular trigger has been established to date.