“Functional Genomics approach to the study of Chinese medicine”中药的功能基因组学研究

活动时间 2005.6.24下午15：00―17：00 

活动地点 理科大楼A-510

主讲人黄岳顺教授中药分子生物学方面的研究的进展，以及香港中药港的建设。报告前，将举行聘任黄岳顺教授为我校顾问教授的受聘仪式。

黄岳顺教授简要介绍和简历

黄岳顺 （Ngok-Shun Ricky Wong）博士曾在美国Phillips Petroleum Company和University of Oklahoma任职，现为香港浸会大学教授，并任该校生物系系主任，兼任香港生物化学和分子生物学学会执行委员，香港大学资助委员会 （UGC）植物和生物技术部执行委员。 他主要从事植物分子生物学的教学工作，在科研方面更专长于植物分子生物学，特别是中药材的分子鉴定和中药现代化，在其研究的领域以及在我国的医药管理部门有相当的知名度。2004年11月我校同意聘请他为华东师范大学顾问教授，趁这次访问我校， 我校将正式颁发给他“华东师范大学顾问教授”聘书。

黄岳顺教授简历

中文姓名: 黄岳顺

英文姓名: Ngok-Shun Ricky Wong

性别: 男

出生年月: 1955年6月

通讯地址: 香港九龙，窝打老道224号，香港浸会大学生物系(Biology Department, Hong Kong Baptist University, 224 Waterloo Road, Hong Kong)
电话：34117050 传真：34115995 Email: rnswong@hkbu.edu.hk

研究兴趣: 植物分子生物学，中药材分子鉴定

教育:
1977  香港中文大学生物化学专业学士学位（荣誉）
1979  香港中文大学生物化学专业硕士学位
1984  美国俄克拉何马大学分子生物学专业博士学位

工作经历:
1984-1987 美国俄克拉何马大学博士后
1987-1988 美国Biotechnology R&D Phillips Petroleum Company研究科学家
1988-1991 美国Bissendorf Biosciences, Inc. 研究科学家
1991-1995 香港浸会大学生物系讲师  
1995-1997 香港浸会大学生物系副教授
1997-2003 香港浸会大学生物系副教授（A级）
2003-present 香港浸会大学生物系系主任， 教授
   
荣誉:
美国俄克拉何马市荣誉市民（1986年由市长Mayor Andy Coats 授予）
1995年入选世界名人录（12版） 

专业学会主要兼职
1991-现在 香港生物化学和分子生物学学会执行委员
2001-现在 香港大学资助委员会 （UGC）植物和生物技术部执行委员

研究基金（2001-现在）

1 FRG/HKBU, (FRG/00-01/II-83) (with Prof K. Chan, Dr H.W. Leung and Dr Z.Z. Zhao)。 Title: A Phytochemical comparison of fresh and processed Danggui Root (Radix Angelica sinesis). Amount awarded: HK$192,000 (Oct. 2001- Sept. 2002)
2 FRG/HKBU*, (FRG/00-01/II-73) (with Prof L. Liang, Dr N.K. Mak and Dr K. Yue). Title: The effect of Sinomenine on angiogenesis.  Amount awarded: HK$200,000 (May 2001-April 2002)
3. FRG/HKBU, (FRG/00-01/II-) (with Prof L. Liang and Dr K. Yue).  Title: The effect of Sinomenine on the gene expression and trans criptional regulation of human synovial fibroblast and mouse lymphocytes.  Amount awarded: HK$200,000 (May 2001-April 2002).
4. FRG/HKBU, (FRG/00-01/II-) (with Prof L. Liang, Dr P.X. Wang and Dr K. Yue.). Title: The effects of polysaccharides from Si Ju Zi decotion on modulation of intestinal epithelia cells and intestinal mucosal immunity. Amount awarded: HK$200,000 (May 2001-April 2002).

5. FRG/HKBU*, (FRG/01-02/I-05). Title: Mechanistic studies on the angio-modulatory activities of ginsenosides. Amount awarded: HK$35,000 (Aug. 2001-Oct. 2001)

6. FRG/HKBU*, (FRG/01-02/II-07). Title: Use of proteomic profiling to investigate the drug action of active ingredients derived from Chinese Medicine. Amount awarded: HK$160,000 (June 2002-June 2003)

7. HKJCICM (with Prof. L. Liu* and staff members of the School of Chinese Medicine). Title: Research and development of a botanical drug product on anti-rheumatoid arthritis from Chinese Medicine. Amount awarded: HK$8,160,000 (April 2003-March 2006).

8. RGC/UGC*(HKBU/2171/03M), (with Prof. K.K.C. Chan, Dr. N.K. Mak and Dr. D.T.P. Fan, Cambridge University). Title: The angio-modulatory activities of Ginsenoside (Rg1). Amount awarded: HK$1,371,000 (September 2003-August 2005).

9. GC/UGC (HKBU/2144/03M), (with Prof. L. Liu* and Prof. Y.Y. Zeng, Jinan University)
Title: Studies on synergistic effects of small molecules from Chinese Medicine plants as enhancer of T cell tolerance induction. Amount awarded: HK$846,000 (September 2003-August 2005).

10. Sponsored research project (with Prof. K.K.C. Chan, Prof. A. Chui and Dr. C.S. Hon)
Title: A prospective randomized controlled clinical trial (RCT) of vitalliver capsule for anti-viral effect on chronic carriers of hepatitis B with and without pre-core mutation. Amount awarded: HK$609,070 (June 2003-May 2004).

获得的专利:

 Title:  Pharmaceutically effective compounds and their use (Rg1)
 Inventors: Cambridge team: Fan, T-P.D., Sengupta, S., Toh, S-A.
   HKBU team:  Wong, R.N.S., Yeung H.W., Leung H.W., Yue,P.Y.T., Wong, D.Y.L.
 Applicant: Cambridge University Technical Services Limited
   Hong Kong Baptist University
 Filed on: July 26, 2001 (British/European Patent Office)
   (Withdraw filing in 2003)

 Title:  Pharmaceutically effective compounds and their use (Rb1)
 Inventors: Cambridge team: Fan, T-P.D., Sengupta, S., Toh, S-A.
   HKBU team:  Wong, R.N.S., Yeung H.W., Leung H.W.
 Applicant: Cambridge University Technical Services Limited
   Hong Kong Baptist University
 Filed on: June 20, 2002 (British/European Patent Office)
   (Withdraw filing in 2003)
 Title:  Application and preparation of a novel indigoids
 Inventors: Dr. Mak, N.K. and Dr. Wong, R.N.S.
 Filed on: China patent application No.: 03133061.4

发表的论文 （1998年以来的代表性论文, 均为通讯作者）
1. Lau, C.K., Wong, R.N.S., Lo, S.C.L. and Kwok, F. (1998) “Refolding of denatured trichosanthin in the presence of GroEL” Biochem. Biophys. Res. Comm., 245: 149-154.
2. Chen S.L., Wong, R.N.S., Lo, V., Chang, S., Chiang, C.D. and Sheh L. (1998) “ Synthesis, DNA cleavage and cytotoxicity of some novel cyclic peptide-2,6-dimethoxy-hydroquinone-3-mercaptoacetic acid conjugates containing D-amino acids” Anti-Cancer Drug Design 13(5): 501-518.
3. Peng, Y., Leung, S.W., Li, W.K., Yeung, H.W., Leung, H.W., Chan, C.L. and Wong, R.N.S. (1998) “中草��防治流行性感冒的研究�F�r及前景”, �d《中草��》,��家��品�O督管理局 29(2): 561-63.
4. Yan, L., Wu, S., Li, H.G., Li J.H., Wong, R.N.S., Shi, Q.L. and Dong, Y.C. (1999) “Role of Tyr70 in the N-glycosidase activity of Neo-trichosanthin” Toxicon 37: 961-72.
5. Peng, Y., Leung, S.W., Leung, H.W., Yeung, H.W., Wong, R.N.S. (1999) “��外抗流感病毒的植物��研究�F�r” , �d《��外�t��--植物��分�浴�14(1): 7-9.
6. Tse, P.M.F., Ng, T.B., Fong, W.P., Wong, R.N.S., Wan, C.C., Mak, N.K. and Yeung, H.W. (1999) “New ribosome-inactivating proteins from seeds and fruits of the bitter gourd Momordica charantia” The International Journal of Biochemistry and Cell Biology 31: 895-901.
7. Kwok, K.H.H., Law, K.B., Wong, R.N.S. and Yung, K.K.L. (1999) “Immuno-lesioning of nerve growth factor p75 receptor-containing neurons in the rat brain by a novel immunotoxin: anti-p75-antimouse IgG-trichosanthin conjugates” Brain Research 846: 154-163.
8. Xia, Xiaofeng, Wang, Shaoxiong, Luo, Jianbang, Wong, R.N.S. and Sui, Sengang (1999) “Trichosanthin can spontaneously penetrate phospholipid monolayer under acid condition” Chinese Science Bulletin 44(20): 1892-1895.
9. Yan, L., Wu, S., Li, H.G., Li, J.H., Wong, R.N.S., Shi, Q.L. and Dong, Y.C. (1999) “Role of Arg163 in the N-glycosidase activity of neo-trichosanthin” Protein Engineering 12: 999-1004.
10. Mak, N.K., Li, W.K., Zhang, M., Wong, R.N.S., Tai, L.S., Yung, K.K.L. and Leung, H.W. (2000) “Effects of euxanthone on neuronal differentiation” Life Sciences 66(4): 347-354.
11. Kwok, K.H.H., Law, K.B., Wong, R.N.S. and Yung, K.K.L. (2000) “Immuno-lesioning of glutamate receptor GluR1-containing neurons in the rat neostriatum using a novel immunotoxin” Cellular and Molecular Neurobiology 20(4): 483-496.
12. Kwok, K.H.H., Wong, R.N.S. and Yung, K.K.L. (2000) “Depletion of Glutamate GluR2 receptor-containing neurons in the rat neostriatum by specific immunotoxin” Brain Research 96: 537-547.
13. Yang, JH., Wong, R.N.S. and Yang, M.S. (2000) “Protective mechanism of metallothionein against copper-1, 10-phenanthroline induced DNA cleavage” Chemico-Biological Interactions 125: 221-232.
14. Bian, W.D., Sun, SQ., Wong, R.N.S. and Zhou, Q. (2000) “Study on thermal unfolding process of trichosanthin by FT-IR spectroscopy” Spectroscopy and Spectral Analysis 20(4): 471-473.
15. Bian, W.D., Wong, R.N.S., Sun, SQ. and Zhou, Q. (2000) “Study on unfolding process of neo-trichosanthin in the presence of GdnHCl” Spectroscopy and Spectral Analysis 20(4): 492-494.
16. Zhang, K.Y.B., Leung, H.W., Yeung, H.W. and Wong, R.N.S. (2001) “Differentiation of Lycium barbarum from its related Lycium species using random amplified polymorphic DNA” Planta Medica 67: 379-381.
17. Mak, N.K., Lung, H.L., Wong, R.N.S., Leung, H.W., Tsang, H.Y. and Leung K.N. (2001) “Expression of Protein Kinase C Isoforms in Euxanthone-induced differentiation of Neuroblastoma cells” Planta Medica 67: 400-405.
18. Narayanan,I.P., Mak, N.K., Luong, P.B. and Wong, R.N.S. (2002) “Isolation and Characterization of New isoforms of trichosanthin from Trichosanthes kirilowii” Plant Science 162: 79-85.
19. Mak, N.K., Wong, R.N.S., Leung K.N. and Fung M.C. (2002) Involvement of tumor necrosis factor (TNF-a) in arsenic trioxide induced apoptotic cell death of murine myeloid leukemia cells Toxicology Letters, 135: 79-87.
20. Cai, Z.W., Qian, T.X., Wong, R.N.S. and Jiang Z.H. (2003) “Liquid chromatography �C electrospray ionization mass spectrometry for metabolism and pharmacokinetic studies of ginsenoside Rg3” Analytica Chimica Acta, 283-293.
21. Mak, N.K., Kok, T.W., Wong, R.N.S., Lam, S.W., Lau Y.K., Leung, W.N., Cheung, N.H., Huang, D.P., Yeung, L.L. and Chang, C.K. (2003) “Photodynamic activities of sulfonamide derivatives of porphycene on nasopharyngeal carcinoma cells” Journal of Biomedical Science, 10(4): 418-429 (2003).
22. Mak, N.K., Leung, C.Y., Wei, X.Y., Shen, X.L., Wong, R.N.S., Leung, K.N. and Fung, M.C. (2004) “Inhibiton of RANTES expression by indirubin in influenza virus-infected human bronchial epithelial cells” Biochemical Pharmacology, 67(1): 167-174.
23. Sengupta S., Toh, S.A., Sellers, L.A., Skepper, J.N., Koolwijk, P., Leung, H.W., Yeung, H.Y., Wong, R.N.S., Sasisekharan, R. and Fan, D.T.P. (2004) “Modulating angiogenesis: the yin and the yang in ginseng” Circulation (in press).
24. Liu, M.J., Wang, Z., Ju, Y., Zhou, J.B., Wang, Y. and Wong, R.N.S. (2004) “The Mitotic-Arresting and Apoptosis-Inducing Effects of Diosgenyl Saponins on Human Leukemia Cell Lines” Biological & Pharmaceutical Bulletin . In press.
25. Liu, L., Han, L., Yue, Y.K., Wong, Y.L., Ha, W.Y., Hu, Y.H., Wang, P.X. and Wong, R.N.S. (2004) “Effects of Si-Jun-Zi Decoction polysaccharides on cell migration and gene expression in wounded rat intestinal epithelial cells”. British Journal of Nutrition. In press.
26. Chan, K., Chui, S.H., Wong, D.Y.L., Ha, W.Y., Chan, C.L. and Wong, R.N.S. (2004) “Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction” Life Sciences. In press.
27. Chui, S.H., Chan, K. and Wong, R.N.S. (2004) “A panel study on the effects of a Chinese medicine suppository, Vigconic VI-28, on insulin-like growth hormone factor 1 and homocysteine in healthy men” Submitted to Methods and Findings in Experimental and Clinical Pharmacology. In press.
28. Liu, M-J., Wang, Z., Ju, Y., Wong, R.N.S. and Wu, Q-Y. (2004) “Calcium homeostasis and mitochondrial hyperpolarization in diosgenin-induced cell cycle arrest and apoptosis”. Biochemical and Biophysical Research Communication. In press.
29. Qian, T.X., Cai, Z.W., Wong, R.N.S. and Jiang, Z.H. (2004) “LC-MS analysis of ginsenoside Rg3 and its major metabolites in biological samples for metabolism study”. Analytical Chemistry. In press.
30. Mak, N.K., Li, K.M., Leung, W.N., Wong, R.N.S., Huang, D.P., Lung, M., Lau, Y.K. and Chang, C.K. (2004) “Involvement of both ER and mitochondria in photokilling of nasopharyngeal carcinoma cells by the photosensitizer Zn-BC-AM” Biochemical Pharmacology. In press.
31. Yue, Y.K., Wong, Y.L., Ha, W.Y., Fung, M.C., Mak, N.K., Yeung, H.W., Liu, L., Chan, K.C., Sengupta, S., Fan, T.P. and Wong, R.N.S. (2004) “Angiomodulatory effects of ginsenoside Rg1 on human umbilical vein endothelial cells”. Journal of Cell Science. In press.
32. Kok, T.W., Yue, Y.K., Mak, N.K., Yue, K.M. and Wong, R.N.S. (2004) “The anti-angiogenic effect of sinomenine” Arthritis Research and Therapy. In press.
33. Wong, W.J., Chan, O.Y., Shek, L.K. and Wong, R.N.S. (2004) “Sequence-specific photo-modification of a supercoiled plasmid DNA by a vanadium(V)-peroxo complex” Submitted to Angewandte Chemie. In press.
34．Sengupta S., Toh, S.A., Sellers, L.A., Skepper,J.N., Koolwijk, P., Leung, H.W., Yeung, H.Y., Wong, R.N.S., Sasisekharan, R. and Fan, D.T.P. "Modulating angiogenesis: the yin and the yang in ginseng" Circulation (in press, 2004)