[校级学术报告] 12月25日 Genetically Engineering BioNanostructures to Develop NanoBiotechnology and Nanom


报告题目:Genetically Engineering BioNanostructures to Develop NanoBiotechnology and Nanomedicine
报告人:Chuanbin Mao,Professor of Stephenson Life Sciences Research Center, Department of Chemistry & Biochemistry, University of Oklahoma,USA.
主 持 人:钱�F  教授
报告时间:12月25日 10:00(周二)
报告地点:闵行生科院534报告厅
报告人简介:毛传斌, 1992年获东北大学学士学位,1997年获该校博士学位,为首届全国百篇优秀博士学位论文的获得者。1997至1999期间,于清华大学从事博士后研究,并先后担任讲师和副教授。2000年初,为美国田纳西大学 (University of Tennessee at Knoxville)访问学者。2000年8月至2005 年7 月,于美国德克萨斯大学(University of Texas at Austin)从事博士后研究。2005年8月,受聘为美国俄克拉何马大学 (University of Oklahoma)化学和生物化学系的助理教授,2010年因杰出研究提前获得美国俄克拉荷马大学的终身副教授职位,评为Presidential Professor。2011年提前升为终身正教授。现在同时为美国伯克利国家重点实验室 (Lawrence Berkeley National Lab) 的客座研究员和俄克拉荷马大学癌症中心的成员。迄今为止,已发表约110篇论文,其中一些发表在国际著名期刊,如Science,PNAS, Angewandte Chemie International Edition,Journal of the American Chemical Society,和Advanced Materials。获得2006年美国俄克拉何马州科技创新研究中心唯一的New Scientist Award,2007年美国国防部乳腺癌研究计划Concept Award,2009年美国国家自然科学基金CAREER Award,2010年中美化学和化学生物学教授联合会Distinguished Junior Faculty Award,2012年美国国防部医学研究计划Discovery Award。现为Wiley出版的SCI国际期刊Microscopy Research and Technique的Senior Associate Editor, 以及4个国际期刊的编委。参与美国和世界其他国家的基金评审。毛传斌课题组研究领域集中在噬菌体展示技术,生物分子材料,细胞-材料相互作用,细胞工程,组织工程,生物纳米技术和纳米医学。
报告内容简介:Nature is rich in bionanostructures that can be used to develop nanobiotechnology and nanomedicine. Three of natural bionanostructures related to bacteria have been studied in my lab, including phage, which is a nanofiber-like virus specifically infecting bacteria, as well as flagella and pili, which are protein nanotubes protruding from the exterior surface of the bacteria and responsible for cell swimming and adhesion. All of these bionanostructures can be genetically engineered to display foreign peptides site-specifically on the surface, enabling us to tune their surface chemistries to control their self-assembly behavior, recognition against cells and tissues, and interaction with biomaterials. This talk will highlight our recent work in this area and focus on the use of these bionanostructures for nano/bio-materials synthesis/assembly, cancer and stem cell targeting, tumor tissue homing, cancer imaging and treatment, stem cell-based therapy, drug/gene delivery, and tissue regeneration. Our work shows that genetically modifiable bionanostructures are unique players in developing novel nano-/bio-materials and nanomedicines.