题 目：The role of COUP-TFII in Prostate Tumor Growth and Metastasis
报告人：Sophia Y. Tsai 教授
主持人：翁杰敏 教授
时 间：9月24日13:30
地 点：闵行校区生命科学学院大楼534报告厅
报告人简介：
Sophia Tsai 1969年毕业于美国加州大学生物化学系，1995年起任美国贝勒医学院分子与细胞生物学系终身教授，2002年获得Michael DeBakey医学博士杰出研究贡献奖, 2009被授予Gordon Cain教授荣誉。Sophia Tsai教授担任Molecular Cellular Biology，Molecular Endocrinology，Endocrinology，Gene Therapy，Nucleic Acid Research，Journal of Biological Chemistry，PNAS，Endocrine Review等多种学术杂志的编委。Sophia Tsai教授的主要研究领域有：基因表达调控、分化与发育生物学、结构及功能的转录因子研究等，已在Nature, Cell, Science, Mol. Cell. Bio, Genes and Development等杂志上发表文章200多篇。
报告内容简介：
COUP-TFII expression is shown to be elevated in prostate cancer patients and its expression correlates with poor prognosis. In my presentation, I will show that PTEN/AKT signaling activates ETS family of transcription factor to regulate the expression of COUP-TFII and COUP-TFII is a major factor mediating PTEN/AKT signaling to induce tumor growth. It is also shown that the expression of COUP-TFII is further enhanced in patients with metastatic prostate cancer. COUP-TFII over-expression suppresses SMAD4/TGF signaling to disrupt the growth barrier induced by SMAD4 in the PTEN null mutant and further augments tumor metastasis. COUP-TFII, being a member of nuclear receptor superfamily, its activity could potentially be regulated by ligands. Thus, COUP-TFII could be an excellent therapeutic target for cancer intervention.
