1.
报告人：徐国良 研究员
报告题目：DNA oxidation towards cell totipotency in mammalian development
时 间：10月14日（周五） 13:30
地 点：闵行校区实验B楼307室
报告人简介：
徐国良，中国科学院生化与细胞生物学研究所研究员，973专项首席科学家。2001年至今担任中国科学院与德国马普学会国际合作青年科学家小组组长，2002年入选中科院“百人计划” ，2002年入选中科院“百人计划”，并获得“国家杰出青年科学基金”。近年来主要从事动物发育过程中DNA甲基化在基因表达调控中的作用及其分子机理的研究，近期连续发表多篇Nature、Science文章。青年科学基金”。近年来主要从事动物发育过程中DNA甲基化在基因表达调控中的作用及其分子机理的研究。


2.
报告人： 俞春东 厦门大学生命科学学院，教授、博士生导师

报告时间：2011年10月17日（周一）14:00-15:30
报告地点：闵行实验B楼307教室

报告摘要：Amplified in breast cancer 1 (AIB1) is a transcriptional coactivator for nuclear receptors and other transcription factors. AIB1 has been identified to play an important role in malignancy of several cancers; however, its involvement in human liver cancer progression remains unclear. Herein we showed that AIB1 protein was overexpressed in 68% of hepatocellular carcinoma (HCC) specimens and promoted HCC progression by enhancing cell proliferation and invasiveness, suggesting that AIB1 plays an important role in HCC development. In addition, we found that Hepatitis B virus X protein (HBx) levels and AIB1 protein levels showed a positive correlation in human HCC specimens. HBx induced a significant accumulation of AIB1 protein and a significant increase of AIB1 protein half-life. HBx could inhibit the interaction between AIB1 and FBW7 to prevent the ubiquitination and degradation of AIB1. Further study revealed that HBx cooperated with AIB1 to enhance MMP-9 expression to promote HCC cell invasiveness. Furthermore, we investigated the role of AIB1 in Cholangiocarcinoma (CCA). We found that down-regulation of AIB1 inhibited CCA cell proliferation by inducing the G2/M arrest through suppressing the Akt pathway. In addition, AIB1 enhanced the chemoresistance of CCA cells at least in part through up-regulating the expression of anti-apoptotic protein Bcl-2. AIB1 regulated the expression of Bcl-2 in CCA cells through activating the Akt pathway as well as suppressing intracellular reactive oxygen species (ROS). AIB1 suppressed ROS by up-regulating Nrf2-targeted antioxindants. AIB1 served as an essential coactivator for Nrf2 by physically interacting with Nrf2 to enhance its transcriptional activity. In conclusion, AIB1 plays an important role in proliferation and chemoresistance of CCA through simultaneous activation of Akt and Nrf2 pathways.

3.
报告人：Prof. Haruhiko KOSEKI
题 目：Polycomb repression in cellular differentiation
时 间：10月19日（周三） 13:30
地 点：闵行校区实验B楼307室
报告人简介：Haruhiko Koseki博士是Yokohama 研究院过敏和免疫研究中心的研究员，主要研究Polycomb Group(PcG)基因在发育过程中表观调控的分子机制。PcG基因不仅在前后位确定，而且在细胞增殖，分化和休眠中起重要作用。Haruhiko Koseki博士研究小组的研究重点主要集中在以下三个方面：PcG蛋白与他们的靶基因的关系；PcG蛋白调控转录抑制的分子机制；PcG蛋白复合体的实时影像。