10月17日 Bing Zhu:Mitotic inheritance of epigenetic information


题  目:Mitotic inheritance of epigenetic information

报告人:Bing Zhu, National Institute of Biological Sciences, Beijing
主持人:翁杰敏  教授
时  间:10月17日 13:30-14:30(周四)

地  点:闵行校区生命科学学院534报告厅

 

报告人简介:朱冰博士是北京生命科学研究所研究员,HHMI青年科学家奖获得者。朱冰1992年获浙江大学学士,1995年获中国水稻研究所硕士学位,1999年获中国科学院上海植物生理研究所博士学位。1999年至2002年在瑞士弗雷德里克—米歇尔研究所进行博士后研究,2002年至2006年在美国霍华德—休斯医学院进行博士后研究。主要研究领域为表观遗传学的生物化学机理。近年来在组蛋白甲基化修饰及甲基化修饰在细胞分裂过程中的传承的分子机制研究中取得了重要成果。

 

报告内容简介:DNA is unarguably the carrier of genetic information. However, DNA sequence alone cannot explain how hundreds of cell types in a complex multi-cellular organism, such as a human individual can possess distinct transcription programs, while sharing the same genetic information. This is believed to be achieved by fine-tuning our genetic information with a so-called “epigenetic” system. To fulfill the two basic tasks challenging the multi-cellular organisms, epigenetic system must simultaneously offer dual characteristics, “Plasticity & Inheritability”. Plasticity allows the transformation of one genome into hundreds of epigenomes and transcriptomes, whereas inheritability permits the maintenance of every single epigenome and its corresponding transcriptome.

Several histone modifications have been shown to be critical in classic epigenetic phenomena, including Position effect variegation, Polycomb silencing and dosage compensation. How newly deposited histones acquire these modifications during/after DNA replication is vital for understanding the mechanisms of epigenetic inheritance. We attempt to address this important question using combinatory approaches by integrating biochemistry, quantitative mass spectrometry and high-throughput sequencing. In this seminar, I will highlight some of our recent progresses along this direction.