大家好！很高兴通知大家，3月19日下午14:00王平教授邀请了美国得克萨斯大学西南医学中心发育生物学和药理学系的蒋进教授前来进行学术交流并在闵行生科院534报告厅举行学术报告，报告题目摘要信息如下，欢迎有兴趣的老师同学准时参加，谢谢！

报告题目：Hippo signaling in organize size control and stem cell regulation

报告人：蒋进，美国得克萨斯大学西南医学中心发育生物学和药理学系教授

主持人： 王平 教授

报告时间：3月19日 14:00

报告地点：闵行生科院534报告厅

报告人简介：蒋进教授现为美国得克萨斯大学西南医学中心发育生物学和药理学系教授。其研究不但发现了Hedgehog, Wnt 以及Hippo 信号通路中的多个的重要成员，而且揭示了这些信号通路的关键调节机制，为人们研究这些与癌症息息相关的信号通路的奠定了基础。蒋进教授的研究成果多次发表在Cell, Nature, Genes & Development,  Developmental Cell等重要学术期刊上。

报告摘要：Cell-cell communication is often mediated by conserved signaling pathways, such as Hedgehog (Hh) and Wingless (Wg)/Wnt pathways. Mutations in genes of Hh and Wg/Wnt pathways have been linked to several types of cancers including basal cell carcinomas, the most common cancer afflicting some 750,000 people every year in the United States alone. The Hh and Wg/Wnt pathways are operating in a similar way among organisms as different as Drosophila and human, which means that we can use animal models to study these important pathways. We are interested in understanding how cell growth and organ size are regulated and how growth and patterning are coordinated. Toward this end, we have identified a new tumor suppressor pathway, called Hippo (Hpo) signaling pathway, which controls organ size by restricting cell proliferation and promoting apoptosis in both Drosophila and mammals. We found that KO of mammalian homologues of Hpo (MST1/2) leads to liver cancer. We are exploring the upstream regulators and downstream effectors of Hpo tumor suppressor pathway. Finally, we are interested in the mechanisms that control adult stem cell proliferation, tissue homeostasis and regeneration. We found that Drosophila adult intestine stem cells undergo excessive proliferation and differentiation to replenish lost cells in response to tissue damage. We are studying how tissue injury leads to changes in stem cell behaviors.